The W. M. Keck Center for Transgene Research develops and uses gene-targeting technology to investigate the pathophysiological roles of the genes of the blood coagulation, anticoagulation, and fibrinolytic pathways in hemostasis, with associated relevance to embryonic development, cancer, infection, and inflammation.
The Center consists of several complementary research programs:
The W.M. Keck Center uses an interdisciplinary approach focused on identifying mechanisms of host/bacteria interaction and regulatory systems important for Group A Streptococcus virulence.
The goal of the W.M. Keck Center's current research is to determine the role of components of hemostasis in the progression of septic acute kidney injury by utilizing in vivo, in vitro and cell-based techniques.
The W.M. Keck Center is working to develop and characterize a rodent model of traumatic brain injury that mimics the human coagulopathic condition, so that mechanisms of the early acute coagulopathy in patients can be more readily assessed.