The two-component regulatory system, CovRS, has been extensively studied due to its key role in regulating pathogenic virulence, and its close association with disease phenotypes. Various studies showed that CovRS was mutated in in vivo isolates from severe invasive infection or animal-passaged derivations, while this two-component sensor/regulator remained intact from isolates of superficial diseases. Previous studies showed that CovRS alters the pathogenic phenotypes by flexibly and precisely regulating a broad spectrum of genes. In order to study the regulation mechanism of CovRS, we used RNA-Seq technology to carry out the comparative transcriptome study for Strept
ococcus pyogenes M23ND strains with covS mutant (M23ND/CovS-) and isogenic wild type (M23ND/CovS+) at logarithm phase (LP) and stationary phase (SP) of growth.
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