Publications
Readnour BM, Ayinuola YA, Russo BT, Liang Z, Lee SW, Ploplis VA, Fischetti VA, Castellino FJ. Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation. J Biol Chem. 2022 Jun;298(6):101940. doi: 10.1016/j.jbc.2022.101940. Epub 2022 Apr 14.PMID: 35430253
Ayinuola YA, Tjia-Fleck S, Readnour BM, Liang Z, Ayinuola O, Paul LN, Lee SW, Fischetti VA, Ploplis VA, Castellino FJ. Relationships Between Plasminogen-Binding M-Protein and Surface Enolase for Human Plasminogen Acquisition and Activation in Streptococcus pyogenes. Front Microbiol. 2022 May 24;13:905670. doi: 10.3389/fmicb.2022.905670. eCollection 2022.PMID: 35685926
Iwaki T, Arakawa T, Sandoval-Cooper MJ, Smith DL, Donahue D, Ploplis VA, Umemura K, Castellino FJ. Plasminogen Deficiency Significantly Reduces Vascular Wall Disease in a Murine Model of Type IIa Hypercholesterolemia. Biomedicines. 2021 Dec 4;9(12):1832. doi: 10.3390/biomedicines9121832.PMID: 34944648
Ayinuola O, Ayinuola YA, Qiu C, Lee SW, Ploplis VA, Castellino FJ. Binding of the kringle-2 domain of human plasminogen to streptococcal PAM-type M-protein causes dissociation of PAM dimers. Microbiologyopen. 2021 Nov;10(6):e1252. doi: 10.1002/mbo3.1252.PMID: 34964287
Vu HM, Hammers DE, Liang Z, Nguyen GL, Benz ME, Moran TE, Higashi DL, Park CJ, Ayinuola YA, Donahue DL, Flores-Mireles AL, Ploplis VA, Castellino FJ, Lee SW. Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution. Front Cardiovasc Med. 2021 Jun 10;8:667554. doi: 10.3389/fcvm.2021.667554. eCollection 2021.PMID: 34179133
Ayinuola YA, Brito-Robinson T, Ayinuola O, Beck JE, Cruz-Topete D, Lee SW, Ploplis VA, Castellino FJ. Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence. J Biol Chem. 2021 Jan-Jun;296:100099. doi: 10.1074/jbc.RA120.016262. Epub 2020 Nov 24.PMID: 33208461
Charles J, Castellino FJ, Ploplis VA. Past and Present Behçet's Disease Animal Models.Curr Drug Targets. 2020;21(16):1652-1663. doi: 10.2174/1389450121666200719010425.PMID: 32682369
Qiu C, Yuan Y, Lee SW, Ploplis VA, Castellino FJ. A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen. Biochem J. 2020 May 15;477(9):1613-1630. doi: 10.1042/BCJ20200197.PMID: 32270857
Carothers KE, Liang Z, Mayfield J, Donahue DL, Lee M, Boggess B, Ploplis VA, Castellino FJ, Lee SW. The Streptococcal Protease SpeB Antagonizes the Biofilms of the Human Pathogen Staphylococcus aureus USA300 through Cleavage of the Staphylococcal SdrC Protein. J Bacteriol. 2020 May 11;202(11):e00008-20. doi: 10.1128/JB.00008-20. Print 2020 May 11.PMID: 32205460
Russo BT, Ayinuola YA, Singh D, Carothers K, Fischetti VA, Flores-Mireles AL, Lee SW, Ploplis VA, Liang Z, Castellino FJ.The M Protein of Streptococcus pyogenes Strain AP53 Retains Cell Surface Functional Plasminogen Binding after Inactivation of the Sortase A Gene. J Bacteriol. 2020 Apr 27;202(10):e00096-20. doi: 10.1128/JB.00096-20. Print 2020 Apr 27.PMID: 32123038
Fields FR, Manzo G, Hind CK, Janardhanan J, Foik IP, Carmo Silva PD, Balsara RD, Clifford M, Vu HM, Ross JN, Kalwajtys VR, Gonzalez AJ, Bui TT, Ploplis VA, Castellino FJ, Siryaporn A, Chang M, Sutton JM, Mason AJ, Lee S.Synthetic AntimicrobialPeptide Tuning Permits Membrane Disruption and Interpeptide Synergy. ACS Pharmacol Transl Sci. 2020 Feb 21;3(3):418-424. doi: 10.1021/acsptsci.0c00001. eCollection 2020 Jun 12.PMID: 32566907
Ploplis VA, Castellino FJ. Host Pathways of Hemostasis that Regulate Group A Streptococcus pyogenes Pathogenicity. Curr Drug Targets. 2020;21(2):193-201. doi: 10.2174/1389450120666190926152914. PMID: 31556853
Urano T, Suzuki Y, Iwaki T, Sano H, Honkura N, Castellino FJ. Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis. Curr Drug Targets. 2019;20(16):1695-1701. doi: 10.2174/1389450120666190715102510. PMID: 31309890
Quek AJH, Mazzitelli BA, Wu G, Leung EWW, Caradoc-Davies TT, Lloyd GJ, Jeevarajah D, Conroy PJ, Sanderson-Smith M, Yuan Y, Ayinuola YA, Castellino FJ, Whisstock JC, Law RHP. Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding. J Mol Biol. 2019 Sep 6;431(19):3804-3813. doi: 10.1016/j.jmb.2019.07.003. Epub 2019 Jul 8. PMID: 31295457
Yuan Y, Ayinuola YA, Singh D, Ayinuola O, Mayfield JA, Quek A, Whisstock JC, Law RHP, Lee SW, Ploplis VA, Castellino FJ. Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes. J Struct Biol. 2019 Jul 10. pii: S1047-8477(19)30154-6. doi: 10.1016/j.jsb.2019.07.005. [Epub ahead of print] PMID: 31301349
Walsh M, Moore EE, Moore H, Thomas S, Lune SV, Zimmer D, Dynako J, Hake D, Crowell Z, McCauley R, Larson EE, Miller M, Pohlman T, Achneck HE, Martin P, Nielsen N, Shariff F, Ploplis VA, Castellino FJ. Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review. Semin Thromb Hemost. 2019 Jun;45(4):354-372. doi: 10.1055/s-0039-1688497. Epub 2019 May 20. PMID: 31108555
Ly D, Donahue D, Walker MJ, Ploplis VA, McArthur JD, Ranson M, Castellino FJ, Sanderson-Smith ML. Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. Microbes Infect. 2019 Apr 19. pii: S1286-4579(19)30051-6. doi: 10.1016/j.micinf.2019.04.004. [Epub ahead of print] PMID: 31009808
Qiu C, Yuan Y, Liang Z, Lee SW, Ploplis VA, Castellino FJ. Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen. J Struct Biol. 2019 May 1;206(2):193-203. doi: 10.1016/j.jsb.2019.03.003. Epub 2019 Mar 14. PMID: 30880082
Qiu C, Yuan Y, Zajicek J, Liang Z, Balsara RD, Brito-Robionson T, Lee SW, Ploplis VA, Castellino FJ. Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization. J Struct Biol. 2018 Nov;204(2):151-164. doi: 10.1016/j.jsb.2018.07.017. Epub 2018 Jul 30.PMID: 30071314
Flaherty RA, Donahue DL, Carothers KE, Ross JN, Ploplis VA, Castellino FJ, Lee SW. Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection. Front Cell Infect Microbiol. 2018 Jul 3;8:211. doi: 10.3389/fcimb.2018.00211. eCollection 2018.PMID: 30018884
Miyajima C, Iwaki T, Umemura K, Ploplis VA, Castellino FJ. Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia.Biomed Res Int. 2018 Jun 7;2018:1878964. doi: 10.1155/2018/1878964. eCollection 2018. PMID: 29977908
Liang Z, Stephens M, Ploplis VA, Lee SW, Castellino FJ .Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes. Genome Announc. 2018 Jun 28;6(26). pii: e00592-18. doi: 10.1128/genomeA.00592-18.PMID: 29954901
Urano T, Castellino FJ, Suzuki Y. Regulation of plasminogen activation on cell surfaces and fibrin. J Thromb Haemost. 2018 May 20. doi: 10.1111/jth.14157. [Epub ahead of print] Review.PMID: 29779246
Miles LA, Baik N, Bai H, Makarenkova HP, Kiosses WB, Krajewski S, Castellino FJ, Valenzuela A, Varki NM, Mueller BM, Parmer RJ. The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation. J Thromb Haemost. 2018 May;16(5):919-932. doi: 10.1111/jth.13988. Epub 2018 Apr 1.PMID: 29495105
Fields FR, Carothers KE, Balsara RD, Ploplis VA, Castellino FJ, Lee SW. Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. J Antibiot (Tokyo). 2018 Feb 20. doi: 10.1038/s41429-018-0032-4. [Epub ahead of print] PMID: 29463889
Holmes A, Zhou N, Donahue DL, Balsara R, Castellino FJ. A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke. Biochem Biophys Res Commun. 2018 Jan 1;495(1):136-144. doi: 10.1016/j.bbrc.2017.10.171. Epub 2017 Oct 31. PMID: 29101031
Yuan Y, Zajicek J, Qiu C, Chandrahas V, Lee SW, Ploplis VA, Castellino FJ. Conformationally organized lysine isosteresin Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen. J Biol Chem. 2017 Sep 8;292(36):15016-15027. doi: 10.1074/jbc.M117.794198. Epub 2017 Jul 19. PMID: 28724633
Bao YJ, Li Y, Liang Z, Agrahari G, Lee SW, Ploplis VA, Castellino FJ. Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers. Pathog Dis. 2017 Jul 31;75(5). doi: 10.1093/femspd/ftx056. PMID: 28520869
Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation. Sci Rep. 2017 Mar 23;7(1):365. doi: 10.1038/s41598-017-00418-y. PMID: 28336948
Glinton K, Beck J, Liang Z, Qiu C, Lee SW, Ploplis VA, Castellino FJ. Variable Region in Streptococcal M-Proteins Provides Stable Binding with Host Fibrinogen for Plasminogen-Mediated Bacterial Invasion. J Biol Chem. 2017 Mar 9. pii: jbc.M116.768937. doi: 10.1074/jbc.M116.768937. [Epub ahead of print] PMID: 28280245
Walsh M, Shreve J, Thomas S, Moore E, Moore H, Hake D, Pohlman T, Davis P, Ploplis V, Piscoya A, Wegner J, Bryant J, Crepinsek A, Lantry J, Sheppard F, Castellino F. Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between". Semin Thromb Hemost. 2017 Mar;43(2):200-212. doi: 10.1055/s-0036-1597900. Epub 2017 Feb 20. PMID: 28219085
Yuan Y, Balsara RD, Zajicek J, Kunda S, Castellino FJ. Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. Biochemistry. 2016 Dec 27;55(51):7112-7122. doi: 10.1021/acs.biochem.6b00962. Epub 2016 Dec 16. PMID: 27981829
Cheriyan J, Balsara RD, Hansen KB, Castellino FJ. Pharmacology of triheteromeric N-Methyl-D-Aspartate Receptors. Neurosci Lett. 2016 Mar 23;617:240-6. doi: 10.1016/j.neulet.2016.02.032. Epub 2016 Feb 23. PMID: 26917100
Bao YJ, Shapiro BJ, Lee SW, Ploplis VA, Castellino FJ. Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps.Sci Rep. 2016 Nov 8;6:36655. Doi: 10.1038/srep36644. PMID: 27821851 [Unknown status]
Higashi DL, Biais N, Donahue DL, Mayfield JA, Tessier CR, Rodriguez K, Ashfeld BL, Luchetti J Ploplis VA, CastellinoFJ, Lee SW. Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis. Nat Microbiol. 2016 Jan 18;1:15004. doi: 10.1038/nmicrobiol.2015.4. PMID: 27571972 [Unknown status]
Bao YJ, Liang Z, Mayfield JA, McShan WM, Lee SW, Ploplis VA, Castellino FJ. Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potential for evolutionary persistence. Microbiology. 2016 Aug; 162(8):1346-59. doi: 10.1099/mic.0.000326 PMID: 27329479 [Unknown status]
Gupta KK, Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4. Biochem Biophys Res Commun. 2016 Aug 26;477(3):503-8. doi: 10.1016/j.bbrc.2016.06.065. PMID: 27317488[Unknown status]
Mamczak CN, Maloney M, Fritz B, Boyer B, Thomas S, Evans E, Ploplis VA, Castellino FJ, McCollester J, Walsh M. Thromboelastography in Orthopaedic Trauma Acute Pelvic Fracture Resuscitation: A Descriptive Pilot Study. J OrthopTrauma. 2016 Jun;30(6):299-305. doi: 10.1097/BOT.0000000000000537. PMID: 27206253 [PubMed - in process]
Yasui H, Donahue DL, Walsh M, Castellino FJ, Ploplis VA University Of Notre Dame. Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury. Am J Physiol Lung Cell Mol Physiol. 2016 May 17:ajplung.00429.2015. doi: 10.1152/ajplung.00429.2015. [Epub ahead of print] PMID: 27190065 [PubMed - as supplied by publisher]
Bao YJ, Liang Z, Mayfield JA, Donahue DL, Carothers KE, Lee SW, Ploplis VA, Castellino FJ. Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity. J Bacteriol. 2016 May 27;198(12):1712-24. doi: 10.1128/JB.01019-15. Print 2016 Jun 15. PMID: 27044623 [PubMed - in process]
Walsh M, Fritz S, Hake D, Son M, Greve S, Jbara M, Chitta S, Fritz B, Miller A, Bader MK, McCollester J, Binz S, Liew-Spilger A, Thomas S, Crepinsek A, Shariff F, Ploplis V, Castellino FJ. Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy. Curr Drug Targets. 2016;17(8):954-70. PMID: 26960340 [PubMed - in process]
Agrahari G, Liang Z, Glinton K, Lee SW, Ploplis VA, Castellino FJ. Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria. J Biol Chem. 2016 Apr 22;291(17):9181-9. doi: 10.1074/jbc.M115.704221. Epub 2016 Mar 4. PMID: 26945067 [PubMed - in process]
Cheriyan J, Balsara RD, Hansen KB, Castellino FJ. Pharmacology of triheteromeric N-Methyl-d-AspertateReceptors Neurosci Lett. 2016 Mar 23;617:240-6. doi: 10.1016/j.neulet.2016.02.032. Epub 2016 Feb 23. PMID: 26917100
Chandrahas V, Glinton K, Liang Z, Donahue DL, Ploplis VA, Castellino FJ. Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes is Required for Activation by its Natural CoinheritedSK2b. J Biol Chem. 2015 Jun 12. pii: jbc.M115.655365. [Epub ahead of print] PMID: 26070561
Kunda S, Yuan Y, Balsara RD, Zaijcek J, Castellino FJ. Hydroxyproline-induced Helical Disruption in Conantokin RI-B Affects Subunit-selective Antagonistic Activities Toward Ion Channels of NMDA Receptors. J Biol Chem. 2015 Jun 5. pii: jbc.M115.650341. [Epub ahead of print] PMID: 26048991
Balsara R, Dang A, Donahue DL, Snow T, Castellino FJ. Conantokin-G Attenuates Detrimental Effects of NMDAR Hyperactivity in an Ischemic Rat Model of Stroke. PLoS One. 2015 Mar 30;10(3):e0122840. doi: 10.1371/journal.pone.0122840. eCollection 2015. PMID: 25822337
Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. PLoS One. 2015 Mar 23;10(3):e0120728. doi: 10.1371/journal.pone.0120728. eCollection 2015. PMID: 25799354
Cheriyan J, Mezes C, Zhou N, Balsara RD, Castellino FJ. Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine. Biochemistry. 2015 Jan 27;54(3):787-94. doi: 10.1021/bi501437s. Epub 2015 Jan 8. PMID: 25544544
Balsara RD, Chapman SE, Sander IM, Donahue DL, Liepert L, Castellino FJ, Leevy WM. Non-invasive imaging and analysis of cerebral ischemia in living rats using positron emission tomography with 18F-FDG. J Vis Exp. 2014 Dec 28;(94). doi: 10.3791/51495.PMID: 25590998
Huang L, Balsara RD, Castellino FJ. Related citations Synthetic conantokin peptides potently inhibit N-methyl-D-aspartate receptor-mediated currents of retinal ganglion cells. J Neurosci Res. 2014 Dec;92(12): 1767-74.doi: 10.1002/jnr.23447.Epub 2014 Jul 10. PMID: 25043917
Bao Y, Liang Z, Booyjzsen C, Mayfield JA, Li Y, Lee SW, Ploplis VA, Song H, Castellino FJ. Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence. J Bacteriol. 2014 Dec;196(23):4089-102. doi: 10.1128/JB.02131-14. Epub 2014 Sep 15. PMID:25225265
Mayfield JA, Liang Z, Agrahari G, Lee SW, Donahue DL, Ploplis VA, Castellino FJ. Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence.PLoS One. 2014 Jun 26;9(6):e100698. doi: 10.1371/journal.pone.0100698. eCollection 2014. PMID:24968349
Bhattacharya S, Liang Z, Quek AJ, Ploplis VA, Law R, Castellino FJ. Dimerization Is Not a Determining Factor for Functional High Affinity Human Plasminogen Binding by the Group A Streptococcal Virulence Factor PAM and Is Mediated by Specific Residues within the PAM a1a2 Domain. J Biol Chem. 2014 Aug 1;289(31):21684-93. doi: 10.1074/jbc.M114.570218. Epub 2014 Jun 24. PMID:24962580
Castellino FJ, Chapman MP, Donahue DL, Thomas S, Moore EE, Wohlauer MV, Fritz B, Yount R, Ploplis V, Davis P, Evans E, Walsh M. Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats. J Trauma Acute Care Surg. 2014 May;76(5):1169-76. doi: 10.1097/TA.0000000000000216. PMID: 24747445
Ploplis VA, Donahue DL, Sandoval-Cooper MJ, MorenoCaffaro M, Sheets P, Thomas SG, Walsh M, Castellino FJ. Systemic Platelet Dysfunction Is the Result of Local Dysregulated Coagulation and Platelet Activation in the Brain in a Rat Model of Isolated Traumatic Brain Injury. J Neurotrauma. 2014 May 21. [Epub ahead of print] PMID:24605991
Zhang Y, Mayfield JA, Ploplis VA, Castellino FJ. The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors. Biochem Biophys Res Commun. 2014 Feb 21;444(4):595-8. doi: 10.1016/j.bbrc.2014.01.109. Epub 2014 Jan 31. PMID:24486550
Balsara RD, Ferreira AN, Donahue DL, Castellino FJ, Sheets PL. Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons. Neuropharmacology. 2014 Apr;79:542-9. doi: 10.1016/j.neuropharm.2014.01.005. Epub 2014 Jan 15. PMID:24440368
Butera D, Wind T, Lay AJ, Beck J, Castellino FJ, Hogg PJ. Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation. J Biol Chem. 2014 Jan 31;289(5):2992-3000. doi: 10.1074/jbc.M113.539924. Epub 2013 Dec 12. PMID:24338014
Kunda S, Cheriyan J, Hur M, Balsara RD, Castellino FJ. Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling. PLoS One. 2013 Nov 18;8(11):e81405. doi: 10.1371/journal.pone.0081405. eCollection 2013. PMID:24260577
Yokota N, Zarpellon A, Chakrabarty S, Bogdanov VY, Gruber A, Castellino FJ, Mackman N, Ellies LG, Weiler H, Ruggeri ZM, Ruf W. Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice. J Thromb Haemost. 2014 Jan;12(1):71-81. doi: 10.1111/jth.12442. PMID:24175924
Donahue DL, Beck J, Fritz B, Davis P, Sandoval-Cooper MJ, Thomas SG, Yount RA, Walsh M, Ploplis VA, Castellino FJ. Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathyfound in humans. J Neurotrauma. 2014 Feb 15;31(4):404-10. doi: 10.1089/neu.2013.3089. Epub 2013 Nov 21. PMID:24040968
Agrahari G, Liang Z, Mayfield JA, Balsara RD, Ploplis VA, Castellino FJ. Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system. J Biol Chem. 2013 Sep 20;288(38):27494-504. doi: 10.1074/jbc.M113.494864. Epub2013 Aug 8. PMID:23928307
van Montfoort ML, Knaup VL, Marquart JA, Bakhtiari K, Castellino FJ, Hack CE, Meijers JC. Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model. Thromb Haemost. 2013 Nov;110(5):1065-73. doi: 10.1160/TH13-05-0429. Epub 2013 Aug 8. PMID:23925504
Sanderson-Smith ML, Zhang Y, Ly D, Donahue D, Hollands A, Nizet V, Ranson M, Ploplis VA, Walker MJ, CastellinoFJ. A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. PLoS Pathog. 2013;9(7):e1003469. doi: 10.1371/journal.ppat.1003469. Epub 2013 Jul 4. PMID:23853591
Zhang Y, Liang Z, Glinton K, Ploplis VA, Castellino FJ. Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains. FEBS Lett. 2013 May 2;587(9):1304-9. doi: 10.1016/j.febslet.2013.02.033. Epub 2013 Mar 7. PMID:23474243
Liang Z, Zhang Y, Agrahari G, Chandrahas V, Glinton K, Donahue DL, Balsara RD, Ploplis VA, Castellino FJ. A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenesstrain influences virulence-associated genes. J Biol Chem. 2013 Mar 1;288(9):6561-73. doi: 10.1074/jbc.M112.442657. Epub 2013 Jan 13. PMID:23316057
Castellino FJ, Liang Z, Davis PK, Balsara RD, Musunuru H, Donahue DL, Smith DL, Sandoval-Cooper MJ, Ploplis VA, Walsh M. Abnormal whole blood thrombi in humans with inherited platelet receptor defects. PLoS One. 2012;7(12):e52878. doi: 10.1371/journal.pone.0052878. Epub 2012 Dec 28. PMID:23300803
Bhattacharya S, Ploplis VA, Castellino FJ. Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination.J Biomed Biotechnol. 2012;2012:482096. doi: 10.1155/2012/482096. Epub 2012 Oct 14. Review. PMID:23118509
Zhang Y, Liang Z, Hsueh HT, Ploplis VA, Castellino FJ. Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase. J Biol Chem. 2012 Dec 7;287(50):42093-103. doi: 10.1074/jbc.M112.417808. Epub 2012 Oct 18. PMID:23086939
Narasaki R, Xu Z, Liang Z, Fung LC, Donahue D, Castellino FJ, Ploplis VA. The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice. J Thromb Haemost. 2012 Dec;10(12):2618-21. doi: 10.1111/jth.12032. No abstract available. PMID:23082983
Davis PK, Musunuru H, Walsh M, Cassady R, Yount R, Losiniecki A, Moore EE, Wohlauer MV, Howard J, Ploplis VA, Castellino FJ, Thomas SG. Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy. Neurocrit Care. 2013 Apr;18(2):201-8. doi: 10.1007/s12028-012-9745-6. PMID:22847397
Davis PK, Musunuru H, Walsh M, Mitra R, Ploplis V, Castellino FJ. The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine. ThrombHaemost. 2012 Sep;108(3):586-8. doi: 10.1160/TH12-04-0222. Epub 2012 Jul 10. No abstract available. PMID:22782135
Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg. 2012 May;214(5):739-46. doi: 10.1016/j.jamcollsurg.2012.01.050. PMID:22520693
Balsara R, Li N, Weber-Adrian D, Huang L, Castellino FJ. Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. Neuropharmacology. 2012 Jun;62(7):2227-38. doi: 10.1016/j.neuropharm.2012.01.018. Epub 2012 Jan 27. PMID:22306487
Walsh M, Thomas SG, Howard JC, Evans E, Guyer K, Medvecz A, Swearingen A, Navari RM, Ploplis V, Castellino FJ. Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. J Extra Corpor Technol. 2011 Sep;43(3):162-7. Review. PMID:22164456
Binny C, McIntosh J, Della Peruta M, Kymalainen H, Tuddenham EG, Buckley SM, Waddington SN, McVey JH, Spence Y, Morton CL, Thrasher AJ, Gray JT, Castellino FJ, Tarantal AF, Davidoff AM, Nathwani AC. AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage. Blood. 2012 Jan 26;119(4):957-66. doi: 10.1182/blood-2011-09-377630. Epub 2011 Dec 1. PMID:22134170
Vetrano S, Ploplis VA, Sala E, Sandoval-Cooper M, Donahue DL, Correale C, Arena V, Spinelli A, Repici A, Malesci A, Castellino FJ, Danese S. Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19830-5. doi: 10.1073/pnas.1107140108. Epub2011 Nov 22. PMID:22109555
Guillen-Ahlers H, Tan J, Castellino FJ, Ploplis VA.Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29. PLoS One. 2011;6(10):e25725. doi: 10.1371/journal.pone.0025725. Epub 2011 Oct 3. PMID:21991341
Han J, Baik N, Kim KH, Yang JM, Han GW, Gong Y, Jardí M, Castellino FJ, Felez J, Parmer RJ, Miles LA. Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen. Blood. 2011 Aug 11;118(6):1653-62. doi: 10.1182/blood-2010-11-316943. Epub 2011 Jun 16. PMID:21680799
Balsara RD, Merryman R, Virjee F, Northway C, Castellino FJ, Ploplis VA. A deficiency of uPAR alters endothelial angiogenic function and cell morphology.Vasc Cell. 2011 May 2;3(1):10. doi: 10.1186/2045-824X-3-10. PMID:21535874
Dai Q, Dong M, Liu Z, Prorok M, Castellino FJ. Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues. J Inorg Biochem. 2011 Jan;105(1):52-7. doi: 10.1016/j.jinorgbio.2010.10.002. Epub 2010 Oct 8. PMID:21134602
Cnudde SE, Prorok M, Jia X, Castellino FJ, Geiger JH. The crystal structure of the calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer. J Biol Inorg Chem. 2011 Feb;16(2):257-66. doi: 10.1007/s00775-010-0722-2. Epub 2010 Nov 10. PMID:21063741
Castellino FJ, Donahue DL, Navari RM, Ploplis VA, Walsh M. An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia. Blood. 2011 Jan 6;117(1):283-9. doi: 10.1182/blood-2010-07-299057. Epub 2010 Sep 21. PMID:20858853
Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood. 2010 Mar 11;115(10):2038-2047. doi: 10.1182/blood-2009-09-244962. Epub2009 Dec 15. PMID:20009036
Xu H, Noria F, Sandoval-Cooper MJ, Menchen H, Donahue DL, Ploplis VA, Castellino FJ. Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice. J Pathol. 2009 Feb;217(3):362-371. doi: 10.1002/path.2454. PMID:18973189 217:362-371.