Yunjuan Bao, PhD

Research Assistiant Professor

Yunjuan - Bao, PhD


2017- present Research Assistiant Professor, W.M. Keck Center for Transgene Research
2014–2017 Visiting Research Associate Professor, W.M. Keck Center for Transgene Research
2012–2016 Associate Principal Investigator, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2010–2012 Senior Technical Officer, Genome Research Centre, Hong Kong, China
2008–2010 Postdoctoral Fellow, University of Hong Kong, Honk Kong, China
2008  Ph.D., University of Hong Kong, Hong Kong, China
2005 M.S., University of Hong Kong, Hong Kong, China
2003 B.S., Shanxi University, Shanxi, China

Research Interests

Bioinformatics, genomics, and proteomics of bacteria

Recent Papers

Bao YJ, Li Y, Liang Z, Agrahari G, Lee SW, Ploplis VA, Castellino FJ. Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers. Pathog Dis. 2017 Jul 31;75(5). doi: 10.1093/femspd/ftx056. PMID: 28520869

Bao YJ, Shapiro BJ, Lee SW, Ploplis VA, Castellino FJ. Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps. Sci Rep. 2016 Nov 8;6:36644. doi: 10.1038/srep36644. PMID: 27821851

Bao YJ, Liang Z, Mayfield JA, McShan WM, Lee SW, Ploplis VA, Castellino FJ. Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potential for evolutionary persistence. Microbiology. 2016 Aug;162(8):1346-59. doi: 10.1099/mic.0.000326. Epub 2016 Jun 21. PMID: 27329479

Bao YJ, Liang Z, Mayfield JA, Donahue DL, Carothers KE, Lee SW, Ploplis VA, Castellino FJ. Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity. J Bacteriol. 2016 May 27;198(12):1712-24. doi: 10.1128/JB.01019-15. Print 2016 Jun 15. PMID: 27044623

Bao YJ, Liang Z, Mayfield JA, Lee SW, Ploplis VA, Castellino FJ. CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants. J Bacteriol. 2015 Oct;197(19):3191-205. doi: 10.1128/JB.00511-15. Epub 2015 Jul 27. PMID: 26216843

Bao Y, Liang Z, Booyjzsen C, Mayfield JA, Li Y, Lee SW, Ploplis VA, Song H, Castellino FJ. Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence. J Bacteriol. 2014 Dec;196(23):4089-102. doi: 10.1128/JB.02131-14. Epub 2014 Sep 15. PMID: 25225265

Gui H, Bao JY, Tang CS, So MT, Ngo DN, Tran AQ, Bui DH, Pham DH, Nguyen TL, Tong A, Lok S, Sham PC, Tam PK, Cherny SS, Garcia-Barcelo MM. Targeted next-generation sequencing on hirschsprung disease: a pilot study exploits DNA pooling. Ann Hum Genet. 2014 Sep;78(5):381-7. doi: 10.1111/ahg.12076. Epub 2014 Jun 20. PMID:24947032

Tong M, Chan KW, Bao JY, Wong KY, Chen JN, Kwan PS, Tang KH, Fu L, Qin YR, Lok S, Guan XY, Ma S. Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma. Cancer Res. 2012 Nov 15;72(22):6024-35. doi: 10.1158/0008-5472.CAN-12-1269. Epub 2012 Sep 18. PMID:22991305

Tse H, Bao JY, Davies MR, Maamary P, Tsoi HW, Tong AH, Ho TC, Lin CH, Gillen CM, Barnett TC, Chen JH, Lee M, Yam WC, Wong CK, Ong CL, Chan YW, Wu CW, Ng T, Lim WW, Tsang TH, Tse CW, Dougan G, Walker MJ, Lok S, Yuen KY. Molecular characterization of the 2011 Hong Kong scarlet fever outbreak. J Infect Dis. 2012 Aug 1;206(3):341-51. doi: 10.1093/infdis/jis362. Epub 2012 May 21. PMID:22615319

Ma S, Bao JY, Kwan PS, Chan YP, Tong CM, Fu L, Zhang N, Tong AH, Qin YR, Tsao SW, Chan KW, Lok S, Guan XY. Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma. Gastroenterology. 2012 Sep;143(3):675-86.e1-12. doi: 10.1053/j.gastro.2012.06.007. Epub 2012 Jun 13. PMID:22705009

Girard SL, Gauthier J, Noreau A, Xiong L, Zhou S, Jouan L, Dionne-Laporte A, Spiegelman D, Henrion E, Diallo O, Thibodeau P, Bachand I, Bao JY, Tong AH, Lin CH, Millet B, Jaafari N, Joober R, Dion PA, Lok S, Krebs MO, Rouleau GA. Increased exonic de novo mutation rate in individuals with schizophrenia. Nat Genet. 2011 Jul 10;43(9):860-3. doi: 10.1038/ng.886.PMID:21743468