Kamlesh Gupta, PhD

Senior Scientist

Kamlesh - Gupta, PhD

Contact Info

Phone: 574-631-2320
Email: Kamlesh.Gupta.19@nd.edu

Biography

2012–present Senior Scientist, W. M. Keck Center for Transgene Research, Notre Dame, IN
2010–2011 Postdoctoral Fellow, Boston Children's Hospital, Harvard Medical School, MA
2006–2010 Postdoctoral Fellow, University of Notre Dame, IN
2000–2005 Ph.D., Biochemistry and Cell Biology, IIT Bombay, India
1998–2000 M.S., Biochemistry, RML University, Faizabad, India
1995–1998 B.S., Biology, DDU University, Gorakhpur, India

Honors & Awards

2008–2009 American Heart Association (AHA) postdoctoral fellowship (Midwest affiliate)
2006 Dr. Gargi Vishnoi Best Ph.D. student Award, IIT Bombay, India
2000–2005 Graduate Fellowship, Ministry of Human Resource Development, India
2000–2001 Teaching Assistant, School of Biosciences & Bioengineering, IIT Bombay, India

Memberships and Committees

2013 Session Co-chair, XIVth International Workshop Molecular and Cellular Biology of Plasminogen Activation (June 4-8, 2013), University of Notre Dame, IN
2009–2010 Reviewer, Biochemistry, Journal of Cell Science, Cancer Chemotherapy & Pharmacology
2006–2009 Member, American Society for Cell Biology (ASCB)
2003 Member, Indian Society for Cell Biology
2002 Member, Indian Association for Cancer Research (IACR)

Research Interests

My current research focuses on understanding the regulation of the fibrinolytic system in physiological processes, and the mechanism by which defects in the fibrinolytic pathway leads to sepsis and other inflammatory diseases.

Recent Papers

Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation. Sci Rep. 2017 Mar 23;7(1):365. doi: 10.1038/s41598-017-00418-y. PMID: 28336948

Gupta KK, Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4. Biochem Biophys Res Commun. 2016 Aug 26;477(3):503-8. doi: 10.1016/j.bbrc.2016.06.065. Epub 2016 Jun 15. PMID: 27317488

Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA. Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. PLoS One. 2015 Mar 23;10(3):e0120728. doi: 10.1371/journal.pone.0120728. eCollection 2015 Mar 23. PMID: 25799354

Gupta KK, Alberico EO, Näthke IS and Goodson HV. Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network. BioEssays. 2014 Sep;36(9):818-826. doi: 10.1002/bies.201400029. Epub 2014 Jun 18. PMID: 24943963.

Gupta KK, Li C, Duan AR, Alberico EO, Kim OV, Alber MS, and Goodson HV. Mechanism for the catastrophe-promoting activity of the microtubule destabilizer Op18/stathmin. Proc. Natl. Acad. Sci. USA. 2013 Dec 17;110(51):20449-20454. doi:10.1073/pnas.1309958110. Epub 2013 Nov 27. PMID:24284166

Karna P, Rida PC, Pannu V, Gupta KK, Dalton WB, Joshi H, Yang VW, Zhou J, and Aneja R. A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering. Cell Death Differ. 2011 Apr;18(4):632-644. doi:10.1038/cdd.2010.133. Epub 2010 Nov 5. PMID:21052096

Mishra RC, Karna P, Gundala SR, Pannu V, Stanton RA, Gupta KK, Robinson M, Lopus M, Wilson L, Henary M, Aneja R. Second generation benzofuranone ring substituted noscapine analogs: Synthesis and biological evaluation. Biochem. Pharmacol. 2011Jul 15;82(2):110-121. doi: 10.1016/j.bcp.2011.03.029. Epub 2011 Apr 8. PMID:21501599

Gupta KK, Joyce MV, Slabbekoorn AR, Zhu ZC, Paulson BA, Boggess B and Goodson HV. Probing interactions between CLIP-170, EB1, and microtubules. J. Mol. Biol. 2010 Feb 5;395(5):1049-1062. doi:10.1016/j.jmb.2009.11.014 Epub 2009 Nov 11. PMID:19913027

Gupta KK, Paulson BA, Folker ES, Charlebois B, Hunt AJ and Goodson HV. Minimal plus-end tracking unit of the cytoplasmic linker protein CLIP-170. J. Biol. Chem. 2009 Mar 13;284(11):6735-6742. doi:10.1074/jbc.M807675200. Epub 2008 Dec 13. PMID:19074770

Zhu ZC, Gupta KK, Slabbekoorn AR, Paulson BA, Folker ES and Goodson HV. Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior. J. Biol. Chem. 2009 Nov 20;284(47):32651-32661. doi:10.1074/jbc.M109.013466. Epub 2009 Sep 23. PMID:19778897

Gupta KK, Bharne SS, Rathinasamy K, Naik NR and Panda D. Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. FEBS J. 2006 Dec;273(23):5320-5332. Epub 2006 Oct 26. PMID: 17069615

Gupta K, Bishop J, Peck A, Brown J, Wilson L and Panda D. Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin. Biochemistry 2004 Jun 1;43(21):6645-6655 PMID:15157098

Beuria TK, Krishnakumar SS, Sahar S, Singh N, Gupta K, Meshram M and Panda D. Glutamate-induced assembly of bacterial cell division protein FtsZ. J. Biol. Chem. 2003 Feb 7;278(6):3735-3741. Epub 2002 Nov 22 PMID:12446699

Zhou J, Gupta K, Aggarwal S, Aneja R, Chandra R, Panda D and Joshi HC. Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation. Mol. Pharmacol. 2003 Apr;63(4):799-807 PMID:12644580

Gupta K and Panda D. Perturbation of microtubule polymerization by quercetin through tubulin binding: a novel mechanism of its antiproliferative activity. Biochemistry. 2002 Oct 29;41(43):13029-13038. PMID:12390030

Zhou J, Gupta K, Yao J, Ye K, Panda D, Giannakakou P and Joshi HC. Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine. J. Biol. Chem. 2002 Oct 18;277(42):39777-39785. Epub 2002 Aug 14. PMID:12183452