Julia E Beck, BA

Graduate Student

Julia E - Beck, BA

Contact Info

Phone: 574-631-2316
Email: Julia.E.Beck.34@nd.edu

Biography

2011–present Graduate student, University of Notre Dame
2011 B.A. DePauw University

Honors & Awards

2014 GAANN Fellow
2011 Inducted fellow of Phi Lambda Upsilon, National Chemistry Honorary Fraternity
2011 Inducted fellow of Phi Alpha Theta, National History Society
2009  Dean’s List
2007–2011 Old Gold Honors Award, DePauw University
2007–2011 Science Research Fellow

Research Interests

Plasminogen is a zymogen that when converted into its active form, plasmin, is able to activate the fibrinolytic system resulting in the degradation of fibrin and extracellular matrices. Group AStreptococcus (GAS) is able to hijack this system leading to a more invasive infection. This process is mediated by proteins found on the surface of the bacteria. One such protein is PAM that binds specifically to one of the lysine binding sites within the kringle domains of plasminogen. My interests are to further understand the role of the lysine binding sites in PAM binding.

Recent Papers

Butera D, Wind T, Lay AJ, Beck J, Castellino FJ, Hogg PJ. Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation. J. Biol Chem. (2014) 289 (5): 2992-3000

Donahue DL, Beck J, Fritz B, Davis P, Sandoval-Cooper MJ, Thomas SG, Yount RA, Walsh M, Ploplis VA, Castellino FJ. Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. J. Neurotrauma. (2014) 31 (4): 404-10